Highlighted Recent Publications
Schreiner DC, Wright A, Baltz ET, Wang T, Cazares C, Gremel CM. Chronic alcohol exposure alters action control via hyperactive premotor corticostriatal activity. Cell Rep. 2023 Jul 25;42(7):112675. doi: 10.1016/j.celrep.2023.112675. Epub 2023 Jun 20. PMID: 37342908.
Cazares C, Schreiner DC, Valencia ML, Gremel CM. Orbitofrontal cortex populations are differentially recruited to support actions. Curr Biol. 2022;32(21):4675-4687.e5. doi:10.1016/j.cub.2022.09.022
Schreiner DC, Cazares C, Renteria R, Gremel CM. Information normally considered task-irrelevant drives decision-making and affects premotor circuit recruitment. Nat Commun. 2022 Apr 19;13(1):2134. doi: 10.1038/s41467-022-29807-2. PMID: 35440120; PMCID: PMC9018678.
Schreiner DC, Yalcinbas EA, Gremel CM. A Push For Examining Subjective Experience in Value-Based Decision-Making. Curr Opin Behav Sci. 2021 Oct;41:45-49. doi: 10.1016/j.cobeha.2021.03.020. Epub 2021 Apr 15. PMID: 34056054; PMCID: PMC8153361.
Renteria R, Cazares C, Baltz ET, Schreiner DC, Yalcinbas EA, Steinkellner T, Hnasko TS, Gremel CM. Mechanism for differential recruitment of orbitostriatal transmission during actions and outcomes following chronic alcohol exposure. Elife. 2021 Mar 17;10:e67065. doi: 10.7554/eLife.67065. PMID: 33729155; PMCID: PMC8016477.
Renteria, R., Baltz, E. T. & Gremel, C. M. (2018) Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits. Nat. Commun. 9, 211.
Additional Publications
Shields CN, Gremel CM. Effects of central amygdala chemogenetic manipulation and prior chronic alcohol exposure on Pavlovian-to-instrumental transfer. Alcohol Clin Exp Res. 2022;46(11):1967-1979. doi:10.1111/acer.14948
Shields CN, Baltz ET, Valencia ML, Gremel CM. Effects of chronic alcohol exposure on motivation-based value updating. Alcohol. 2022 Jun;101:53-64. doi: 10.1016/j.alcohol.2022.03.004. Epub 2022 Apr 8. PMID: 35405249.
Bonm AV, Elezgarai I, Gremel CM, Viray K, Bamford NS, Palmiter RD, Grandes P, Lovinger DM, Stella N. Control of exploration, motor coordination and amphetamine sensitization by cannabinoid CB1 receptors expressed in medium spiny neurons. Eur J Neurosci. 2021 Aug;54(3):4934-4952. doi: 10.1111/ejn.15381. Epub 2021 Jul 13. PMID: 34216157; PMCID: PMC9377695.
Shields, C. N., & Gremel, C. M. (2021). Prior chronic alcohol exposure enhances Pavlovian-to-instrumental transfer. Alcohol, 96, 83–92. https://doi.org/10.1016/j.alcohol.2021.07.004
Yalcinbas EA, Cazares C, Gremel CM. Call for a more balanced approach to understanding orbital frontal cortex function. Behav Neurosci. 2021 Apr;135(2):255-266. doi: 10.1037/bne0000450. PMID: 34060878.
Cazares C, Schreiner DC, Gremel CM. Different Effects of Alcohol Exposure on Action and Outcome-Related Orbitofrontal Cortex Activity. eNeuro. 2021 Apr 20;8(2):ENEURO.0052-21.2021. doi: 10.1523/ENEURO.0052-21.2021. PMID: 33785522; PMCID: PMC8174034.
Lovinger DM, Gremel CM. A Circuit-Based Information Approach to Substance Abuse Research. Trends Neurosci. 2021 Feb;44(2):122-135. doi: 10.1016/j.tins.2020.10.005. Epub 2020 Nov 6. PMID: 33168235; PMCID: PMC7856012.
Shields CN, Gremel CM. Review of Orbitofrontal Cortex in Alcohol Dependence: A Disrupted Cognitive Map? Alcohol Clin Exp Res. 2020 Oct;44(10):1952-1964. doi: 10.1111/acer.14441. Epub 2020 Sep 20. PMID: 32852095.
Cuzon Carlson, V. C., Gremel, C. M., & Lovinger, D. M. (2020) Gestational alcohol exposure disrupts cognitive function and striatal circuits in adult offspring. Nature Communications, 11(1), 2555.
Renteria R, Cazares C, Gremel CM. Habitual Ethanol Seeking and Licking Microstructure of Enhanced Ethanol Self-Administration in Ethanol-Dependent Mice. Alcohol Clin Exp Res. 2020 Apr;44(4):880-891. doi: 10.1111/acer.14302. Epub 2020 Feb 25. PMID: 32020644; PMCID: PMC7238766.
Schreiner, D. C., Renteria, R. & Gremel, C. M. (2019) Fractionating the all‐or‐nothing definition of goal‐directed and habitual decision‐making. J. Neurosci. Res. jnr.24545
Schreiner, D. C. & Gremel, C. M. (2018) Orbital Frontal Cortex Projections to Secondary Motor Cortex Mediate Exploitation of Learned Rules. Sci. Rep. 8, 1–12.
Baltz, E. T., Yalcinbas, E. A., Renteria, R. & Gremel, C. M. (2018) Orbital frontal cortex updates state-induced value change for decision-making. eLife 7.
Gremel CM & Lovinger DL (2016). Associative and sensorimotor corticobasal ganglia circuit roles in effects of abused drugs. Genes, Brain, & Behavior. 16(1): 71-85.
Gremel CM, Chancey JH, Atwood BK, Luo GL, Neve R, Deisseorth K M, Lovinger DM, Costa RM (2016) Endocannabinoid modulation of orbitostriatal circuits gates habit formation. Neuron, 90, 1-13.
Barker JM, Corbit LH, Robinson DL, Gremel CM, Gonzales RA, Chandler LJ (2015) Corticostriatal circuitry andhabitual ethanol seeking. Invited review of Volterra Conference Proceeding, Alcohol, 49: 817-834
Holroyd KB, Adrover MF, Fuino RL, Bock R, Kaplan AR, Gremel CM, Rubinstein M, Alvarez VA (2015) Loss of feedback inhibition via D2 autoreceptors enhances acquisition of cocaine taking and reactivity to drug-paired cues., Neuropsychopharmacology, doi:10.1038/npp.2014.336
Gremel CM, Costa RM (2014) Secondary motor cortex is necessary for goal-directed actions. Frontiers Computational Neuroscience, 7(110): doi:10.3389/fncom.2013.00110
Gremel CM & Costa RM (2013) Orbitofrontal and striatal circuits dynamically encode the shift between goal-directedand habitual actions. Nature Communications, 4:2264 doi: 10.1038/ncomms3264.
Bock R, Shin JH, Dobi A, Markey E, Kramer PF, Funo R, Kaplan AR, Gremel CM, Christensen CH, Androver MF, Alvarez VA (2013) Synaptic potentiation at accumbal indirect-pathway neurons protects against cocaine addictive-like behaviors. Nature Neuroscience, 16(5): 632-638.
Gremel CM, Young EM, Cunningham CL (2010) Blockade of opioid receptors in anterior cingulate cortex disrupts ethanol-seeking behavior in mice. Behav Brain Res, 219(2): 358-362.
Gremel CM & Cunningham CL (2010) Effects of disconnection of amygdala dopamine and nucleus accumbens N-methyl-d-aspartate receptors on ethanol-seeking behavior in mice. Eur J Neurosci. 31(1):148-155.
Gremel CM & Cunningham CL (2009) Involvement of amygdala dopamine and nucleus accumbens NMDA receptors in expression of ethanol seeking behavior in mice. Neuropsychopharm. 34: 1443-1453.
Gremel CM & Cunningham CL (2008) Roles of the nucleus accumbens and amygdala in the acquisition and expression of ethanol conditioned behavior in mice. J. Neurosci, 28(5): 1076-1084.
Cunningham CL, Gremel CM, Groblewski PA (2009) Genetic influences on conditioned taste aversion. In S. Reilly & T. R. Schachtman (Eds.), Conditioned taste aversion: Behavioral and neural processes (pp. 387-421). New York: Oxford University Press.
Cunningham CL & Gremel CM (2006) Proximal ethanol pretreatment interferes with acquisition of ethanol-induced conditioned place preference. Pharm, Biochem, Behav, 85(3): 612-619.
Gremel CM, & Cunningham CL (2007) Role of test activity in ethanol-induced disruption of place preference expression in mice. Psychopharm, 191(2): 195-202.
Cunningham CL, Gremel CM, Groblewski PA (2006) Drug-induced conditioned place preference and aversion in mice. Nature Protocols, 1(4): 1662-1670.
Gremel CM, Gabriel KA, Cunningham CL (2006) Topiramate does not affect the acquisition or expression of ethanol conditioned place preference by ethanol in mice. Alcohol Clin Exp Res, 30(5): 783-790.
Bechtholt AJ, Gremel CM, Cunningham CL (2004) Handling blocks expression of conditioned place aversion butnot conditioned place preference produced by ethanol in mice. Pharm. Biochem. Behav, 79(4): 739 – 744.